Article
Lack of association between polymorphic microsatellites of the VMAT2 gene and Parkinson's disease in Japan.
Journal of the neurological sciences - 15 May 2005
Kariya Shingo, Hirano Makito, Takahashi Nobuyuki, Furiya Yoshiko, Ueno Satoshi
Abstract excerpt
The etiology of Parkinson's disease (PD) remains unclear; however, generation of reactive oxygen species during oxidation of dopamine (DA) could be one of the factors leading to selective loss of nigral dopaminergic neurons in PD. Vesicular monoamine transporter type 2 (VMAT2) proteins in nerve terminals uptake and partition DA from neuronal cytoplasm into synaptic vesicles. Therefore, alterations of VMAT2...
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