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Article

Gain-of-function haplotypes in the vesicular monoamine transporter promoter are protective for Parkinson disease in women

8 Dec 2005

Abstract excerpt

The vesicular monoamine transporter can protect against toxins that induce an acute parkinsonian syndrome. It has been hypothesized that cytoplasmic dopamine has subacute toxic effects in Parkinson Disease (PD) leading to neuronal death and clinical symptoms. Regulatory polymorphisms in the brain form of the vesicular monoamine transporter (VMAT2) which affect its quantitative expression might therefore serve as...

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PMID: 16339215
DOI: 10.1093/hmg/ddi445

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Gain-of-function haplotypes in the vesicular monoamine transporter promoter are protective for Parkinson disease in womenPMID 16339215Read ↗

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