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Article

Wrapping effects within a proposed function-rescue strategy for the Y220C oncogenic mutation of protein p53.

PloS one - 1 Jan 2013

Accordino Sebastián R, Rodríguez Fris J Ariel, Appignanesi Gustavo A

Abstract excerpt

Soluble proteins must protect their structural integrity from water attack by wrapping interactions which imply the clustering of nonpolar residues around the backbone hydrogen bonds. Thus, poorly wrapped hydrogen bonds constitute defects which have been identified as promoters of protein associations since they favor the removal of hydrating molecules. More specifically, a recent study of our group has shown...

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PMID: 23365691
DOI: 10.1371/journal.pone.0055123
PMCID: PMC3554699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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