Article
Functionality of wrapping defects in soluble proteins: what cannot be kept dry must be conserved.
Journal of molecular biology - 19 Mar 2004
Fernández Ariel
Abstract excerpt
Soluble proteins preserve their structure only if a sufficient number of non-polar groups are clustered around the backbone hydrogen bonds, protecting them from water attack. When these bonds are not properly wrapped or dehydrated intramolecularly, structural integrity can be preserved through binding partnerships. This is because insufficiently wrapped hydrogen bonds are inherently adhesive and become better...
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