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Article

Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant.

Chemistry & biology - 29 Jan 2010

Basse Nicolas, Kaar Joel L, Settanni Giovanni, Joerger Andreas C, Rutherford Trevor J, Fersht Alan R

Abstract excerpt

The p53 cancer mutation Y220C induces formation of a cavity on the protein's surface that can accommodate stabilizing small molecules. We combined fragment screening and molecular dynamics to assess the druggability of p53-Y220C and map ligand interaction sites within the mutational cavity. Eluci...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20142040
DOI: 10.1016/j.chembiol.2009.12.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20142040-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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