Article
Cooperating gene mutations in childhood acute myeloid leukemia with special reference on mutations of ASXL1, TET2, IDH1, IDH2, and DNMT3A.
Blood - 11 Apr 2013
Liang Der-Cherng, Liu Hsi-Che, Yang Chao-Ping, Jaing Tang-Her, Hung Iou-Jih, Yeh Ting-Chi, Chen Shih-Hsiang, Hou Jen-Yin, Huang Ying-Jung, Shih Yu-Shu, Huang Yu-Hui, Lin Tung-Huei, Shih Lee-Yung
Abstract excerpt
Gene mutations involving epigenetic regulators recently have been described in adult acute myeloid leukemia (AML). Similar studies are limited in children. We analyzed gene mutations and cooperation in pediatric AML with special reference on mutated epigenetic regulators. Nineteen gene mutations, including 8 class I genes, 4 class II genes, WT1 and TP53 (class III), and 5 epigenetic regulator genes (class IV),...
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