Article
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
Circulation. Cardiovascular genetics - 1 Apr 2013
Wu Jason H Y, Lemaitre Rozenn N, Manichaikul Ani, Guan Weihua, Tanaka Toshiko, Foy Millennia, Kabagambe Edmond K, Djousse Luc, Siscovick David, Fretts Amanda M, Johnson Catherine, King Irena B, Psaty Bruce M, McKnight Barbara, Rich Stephen S, Chen Yii-Der I, Nettleton Jennifer A, Tang Weihong, Bandinelli Stefania, Jacobs David R, Browning Brian L, Laurie Cathy C, Gu Xiangjun, Tsai Michael Y, Steffen Lyn M, Ferrucci Luigi, Fornage Myriam, Mozaffarian Dariush
Abstract excerpt
BACKGROUND- Palmitic acid (16:0), stearic acid (18:0), palmitoleic acid (16:1n-7), and oleic acid (18:1n-9) are major saturated and monounsaturated fatty acids that affect cellular signaling and metabolic pathways. They are synthesized via de novo lipogenesis and are the main saturated and monounsaturated fatty acids in the diet. Levels of these fatty acids have been linked to diseases including type 2 diabetes...
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