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Article

Genetically determined ABCB5 functionality correlates with pigmentation phenotype and melanoma risk.

Biochemical and biophysical research communications - 5 Jul 2013

Lin Jennifer Y, Zhang Mingfeng, Schatton Tobias, Wilson Brian J, Alloo Allireza, Ma Jie, Qureshi Abrar A, Frank Natasha Y, Han Jiali, Frank Markus H

Abstract excerpt

ABCB5 is a multidrug resistance (MDR) member of the ATP-binding cassette (ABC) superfamily of active transporters and represents a marker for chemoresistant malignant melanoma-initiating cells. ABCB5 expression is closely linked to tumorigenicity and progression of diverse human malignancies, including melanoma, and is functionally required for tumor growth. Here, we genotyped 585 melanoma cases and 605...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Hair Color

Share to Melanins

Share to Melanoma

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Share to Pigmentation

Source

Open in PubMed Open full text

Identifiers

PMID: 23770371
DOI: 10.1016/j.bbrc.2013.06.006
PMCID: PMC3756469

Genes

ABCB5

Variants

rs2301641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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