Site-directed mutagenesis of the proposed catalytic amino acids of the Sindbis virus capsid protein autoprotease.

doi:10.1128/JVI.64.6.3069-3073.1990

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Article

Site-directed mutagenesis of the proposed catalytic amino acids of the Sindbis virus capsid protein autoprotease.

Journal of virology - 1 Jun 1990

Hahn C S, Strauss J H

Abstract excerpt

The structural proteins of Sindbis virus are translated as a polyprotein precursor that is cleaved upon translation. The capsid protein is postulated to be a serine protease that releases itself from the N terminus of the nascent polyprotein by autoproteolysis. We have tested the importance in au...

Topics

Amino Acid Sequence
Animals
Binding Sites
Capsid
Codon
Electrophoresis, Polyacrylamide Gel
Mutation
Plasmids
Protein Biosynthesis
RNA, Messenger
Serine Endopeptidases
Sindbis Virus
Viral Structural Proteins

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