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Zinc-Finger Antiviral Protein Inhibits XMRV Infection

15 Jun 2012

Abstract excerpt

BACKGROUND: The zinc-finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses, including Moloney murine leukemia virus (MoMLV), HIV-1, and certain alphaviruses and filoviruses. ZAP binds to specific viral mRNAs and recruits cellular mRNA degradation machinery to degrade the target RNA. The common features of ZAP-responsive RNA sequences remain elusive and thus...

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PMID: 22720057
DOI: 10.1371/journal.pone.0039159

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