Article
Blood outgrowth endothelial cells from Hereditary Haemorrhagic Telangiectasia patients reveal abnormalities compatible with vascular lesions.
Cardiovascular research - 1 Nov 2005
Fernandez-L Africa, Sanz-Rodriguez Francisco, Zarrabeitia Roberto, Pérez-Molino Alfonso, Hebbel Robert P, Nguyen Julia, Bernabéu Carmelo, Botella Luisa-Maria
Abstract excerpt
OBJECTIVE: Hereditary haemorrhagic telangiectasia (HHT) is originated by mutations in endoglin (HHT1) and ALK1 (HHT2) genes. The purpose of this work was to isolate and characterize circulating endothelial cells from HHT patients. METHODS: Pure primary cultures of blood outgrowth endothelial cells (BOECs) were obtained from 50 ml of peripheral blood by selection on collagen plates with endothelial medium....
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