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Article

Association of the K153R polymorphism in the myostatin gene and extreme longevity.

Age (Dordrecht, Netherlands) - 1 Dec 2013

Garatachea Nuria, Pinós Tomàs, Cámara Yolanda, Rodríguez-Romo Gabriel, Emanuele Enzo, Ricevuti Giovanni, Venturini Letizia, Santos-Lozano Alejandro, Santiago-Dorrego Catalina, Fiuza-Luces Carmen, Yvert Thomas, Andreu Antoni L, Lucia Alejandro

Abstract excerpt

The myostatin (MSTN) gene is a candidate to influence extreme longevity owing to its role in modulating muscle mass and sarcopenia and especially in inhibiting the main nutrient-sensing pathway involved in longevity, i.e. mammalian target of rapamycin. We compared allele/genotype distributions of the exonic MSTN variants K153R (rs1805086), E164K (rs35781413), I225T and P198A, in Spanish centenarians (cases, n =...

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Source

Open in PubMed Open full text

Identifiers

PMID: 23354683
DOI: 10.1007/s11357-013-9513-3
PMCID: PMC3825013

Genes

MSTN

Variants

rs1805086
rs1805086
rs1805086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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