Article
K153R polymorphism in myostatin gene increases the rate of promyostatin activation by furin.
FEBS letters - 30 Jan 2015
Szláma György, Trexler Mária, Buday László, Patthy László
Abstract excerpt
Recent studies demonstrated an association between the K153R polymorphism in the myostatin gene with extreme longevity, lower muscle strength and obesity but the molecular basis of these associations has not been clarified. Here, we show that the K153R mutation significantly increases the rate of proteolysis of promyostatin by furin, but has no effect on the activity of the latent complex or the cleavage of the...
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