Are 'endurance' alleles 'survival' alleles? Insights from the ACTN3 R577X polymorphism.

doi:10.1371/journal.pone.0017558

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Article

Are 'endurance' alleles 'survival' alleles? Insights from the ACTN3 R577X polymorphism.

PloS one - 3 Mar 2011

Fiuza-Luces Carmen, Ruiz Jonatan R, Rodríguez-Romo Gabriel, Santiago Catalina, Gómez-Gallego Félix, Yvert Thomas, Cano-Nieto Amalia, Garatachea Nuria, Morán María, Lucia Alejandro

Abstract excerpt

Exercise phenotypes have played a key role for ensuring survival over human evolution. We speculated that some genetic variants that influence exercise phenotypes could be associated with exceptional survival (i.e. reaching ≥100 years of age). Owing to its effects on muscle structure/function, a potential candidate is the Arg(R)577Ter(X) polymorphism (rs1815739) in ACTN3, the structural gene encoding the skeletal...

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PMID: 21407828
DOI: 10.1371/journal.pone.0017558
PMCID: PMC3048287

Genes

ACTN3

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