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Article

Muscle-Related Polymorphisms (MSTN rs1805086 and ACTN3 rs1815739) Are Not Associated with Exceptional Longevity in Japanese Centenarians.

PloS one - 1 Jan 2016

Fuku Noriyuki, Alis Rafael, Yvert Thomas, Zempo Hirofumi, Naito Hisashi, Abe Yukiko, Arai Yasumichi, Murakami Haruka, Miyachi Motohiko, Pareja-Galeano Helios, Emanuele Enzo, Hirose Nobuyoshi, Lucia Alejandro

Abstract excerpt

Myostatin (MSTN) and α-actinin-3 (ACTN3) genes are potentially associated with preservation of muscle mass and oxidative capacity, respectively. To explore the possible role of these genes in exceptional longevity (EL), the allele/genotype frequency distribution of two polymorphisms in MSTN (rs1805086, K153R) and ACTN3 (rs1815739, R577X) was studied in Japanese centenarians of both sexes (n = 742) and healthy...

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Source

Open in PubMed Open full text

Identifiers

PMID: 27861536
DOI: 10.1371/journal.pone.0166605
PMCID: PMC5115755

Genes

ACTN3
MSTN

Variants

rs1805086
rs1805086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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