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Article

Modulation of p38 MAPK signaling enhances dendritic cell activation of human CD4+ Th17 responses to ovarian tumor antigen.

Cancer immunology, immunotherapy : CII - 1 May 2013

Cannon Martin J, Goyne Hannah E, Stone Pamela J B, Macdonald Laura J, James Lindsey E, Cobos Everardo, Chiriva-Internati Maurizio

Abstract excerpt

The recent finding that Th17 infiltration of ovarian tumors positively predicts patient outcomes suggests that Th17 responses play a protective role in ovarian tumor immunity. This observation has led to the question of whether Th17 cells could be induced or expanded to therapeutic advantage by tumor vaccination. In this study, we show that treatment of ovarian tumor antigen-loaded, cytokine-matured human...

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Share to Antigens, Neoplasm
Share to Dendritic Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme-Linked Immunosorbent Assay

Share to Indoleamine-Pyrrole 2,3,-Dioxygenase

Share to Lymphocytes

Share to p38 Mitogen-Activated Protein Kinases

Share to T-Lymphocytes, Cytotoxic

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Source

Open in PubMed Open full text

Identifiers

PMID: 23354626
DOI: 10.1007/s00262-013-1391-0
PMCID: PMC3915291

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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