Article
Day-4 myeloid dendritic cells pulsed with whole tumor lysate are highly immunogenic and elicit potent anti-tumor responses.
PloS one - 1 Jan 2011
Chiang Cheryl Lai-Lai, Hagemann Andrea R, Leskowitz Rachel, Mick Rosemarie, Garrabrant Thomas, Czerniecki Brian J, Kandalaft Lana E, Powell Daniel J, Coukos George
Abstract excerpt
"Day-7" myeloid DCs are commonly used in the clinic. However, there is a strong need to develop DCs faster that have the same potent immunostimulatory capacity as "Day-7" myeloid DCs and at the same time minimizing time, labor and cost of DC preparations. Although "2 days" DCs can elicit peptide-specific responses, they have not been demonstrated to engulf, process and present complex whole tumor lysates, which...
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