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Article

Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility.

Developmental biology - 15 Apr 2013

Roach Gillian, Heath Wallace Rachel, Cameron Amy, Emrah Ozel Rifat, Hongay Cintia F, Baral Reshica, Andreescu Silvana, Wallace Kenneth N

Abstract excerpt

The vertebrate intestinal epithelium is renewed continuously from stem cells at the base of the crypt in mammals or base of the fold in fish over the life of the organism. As stem cells divide, newly formed epithelial cells make an initial choice between a secretory or enterocyte fate. This choice has previously been demonstrated to involve Notch signaling as well as Atonal and Her transcription factors in both...

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Identifiers

PMID: 23353550
DOI: 10.1016/j.ydbio.2013.01.013
PMCID: PMC3636723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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