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Heterologous expression and engineering studies of labyrinthopeptins, class III lantibiotics from Actinomadura namibiensis.

Chemistry & biology - 24 Jan 2013

Krawczyk Joanna M, Völler Ginka H, Krawczyk Bartlomiej, Kretz Julian, Brönstrup Mark, Süssmuth Roderich D

Abstract excerpt

Labyrinthopeptins are class III lantibiotics produced by the actinomycete Actinomadura namibiensis. The most characteristic structural feature is the posttranslationally installed triamino triacid labionin with a quaternary α-carbon. In addition to the unique structure, labyrinthopeptin A2 possess remarkable antiviral and antiallodynic biological activities. To harness the substrate tolerance of the biosynthetic...

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PMID: 23352145
DOI: 10.1016/j.chembiol.2012.10.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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