Article
Increasing the Antimicrobial Activity of Nisin-Based Lantibiotics against Gram-Negative Pathogens.
Applied and environmental microbiology - 15 Jun 2018
Li Qian, Montalban-Lopez Manuel, Kuipers Oscar P
Abstract excerpt
Lantibiotics are ribosomally synthesized and posttranslationally modified antimicrobial compounds containing lanthionine and methyl-lanthionine residues. Nisin, one of the most extensively studied and used lantibiotics, has been shown to display very potent activity against Gram-positive bacteria, and stable resistance is rarely observed. By binding to lipid II and forming pores in the membrane, nisin can cause...
Topics
- Anti-Bacterial Agents
- Bacteriocins
- Escherichia coli
- Gram-Negative Bacteria
- Microbial Sensitivity Tests
- Mutation
- Nisin
- Pseudomonas aeruginosa
- Recombinant Fusion Proteins