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Article

Nodal promotes aggressive phenotype via Snail-mediated epithelial-mesenchymal transition in murine melanoma.

Cancer letters - 1 Jun 2013

Fang Rui, Zhang Ge, Guo Qiang, Ning Fen, Wang Hao, Cai Shaohui, Du Jun

Abstract excerpt

Nodal, an important embryonic morphogen, has been reported to function in tumorigenesis. Here we report for the first time that Nodal promotes malignancy by inducing epithelial-mesenchymal transition (EMT) in B16 murine melanoma. These cells displayed increased migration and invasion abilities upon treating with Nodal, accompanying with typical phenotype changes of EMT. In contrast, Nodal knockdown or blocking...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23348697
DOI: 10.1016/j.canlet.2013.01.014

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