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Article

Betulinic acid suppresses NGAL-induced epithelial-to-mesenchymal transition in melanoma.

Biological chemistry - 1 Jun 2013

Gheorgheosu Dorina, Jung Michaela, Ören Bilge, Schmid Tobias, Dehelean Cristina, Muntean Danina, Brüne Bernhard

Abstract excerpt

Betulinic acid (BA) exhibits antitumoral activity by blocking proliferation, invasion, and angiogenesis. However, the impact of BA on epithelial-to-mesenchymal transition (EMT), a hallmark of cancer metastasis induced among others by neutrophil gelatinase-associated lipocalin (NGAL), remains unknown. The present study aimed at determining the effect of BA on NGAL-induced EMT. In A375 melanoma cells, BA...

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Identifiers

PMID: 23399635
DOI: 10.1515/hsz-2013-0106

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