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Article

Wnt-signaling enhances neural crest migration of melanoma cells and induces an invasive phenotype.

Molecular cancer - 17 Feb 2018

Sinnberg Tobias, Levesque Mitchell P, Krochmann Jelena, Cheng Phil F, Ikenberg Kristian, Meraz-Torres Francisco, Niessner Heike, Garbe Claus, Busch Christian

Abstract excerpt

BACKGROUND: During embryonic development Wnt family members and bone morphogenetic proteins (BMPs) cooperatively induce epithelial-mesenchymal transition (EMT) in the neural crest. Wnt and BMPs are reactivated during malignant transformation in melanoma. We previously demonstrated that the BMP-antagonist noggin blocked the EMT phenotype of melanoma cells in the neural crest and malignant invasion of melanoma...

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Identifiers

PMID: 29454361
DOI: 10.1186/s12943-018-0773-5
PMCID: PMC5816360

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