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Article

PKSP-dependent reduction of phagolysosome fusion and intracellular kill of<i>Aspergillus fumigatus</i>conidia by human monocyte-derived macrophages

1 Dec 2002

Abstract excerpt

Previously, we described the isolation of an Aspergillus fumigatus mutant producing non-pigmented conidia, as a result of a defective polyketide synthase gene, pksP (polyketide synthase involved in pigment biosynthesis). The virulence of the pksP mutant was attenuated in a murine animal infection model and its conidia showed enhanced susceptibility towards damage by monocytes in vitro. Because macrophage-mediated...

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PMID: 12464010
DOI: 10.1046/j.1462-5822.2002.00228.x

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