Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CCL21 Facilitates Chemoresistance and Cancer Stem Cell‐Like Properties of Colorectal Cancer Cells through AKT/GSK‐3 β /Snail Signals

28 Dec 2015

Abstract excerpt

Some evidence indicated that chemoresistance associates with the acquisition of cancer stem-like properties. Recent studies suggested that chemokines can promote the chemoresistance and stem cell properties in various cancer cells, while the underling mechanism is still not completely illustrated. In our study, we found that CCL21 can upregulate the expression of P-glycoprotein (P-gp) and stem cell property...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cytokine Signaling Pathways and Interactions
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27057280
DOI: 10.1155/2016/5874127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CCL21 Facilitates Chemoresistance and Cancer Stem Cell‐Like Properties of Colorectal Cancer Cells through AKT/GSK‐3 β /Snail SignalsPMID 27057280Read ↗

[Influence of CCL21 on the invasion and metastasis of colorectal cancer].Semantic proximity Read ↗

Bufalin reverses multidrug resistance by regulating stemness through the CD133/nuclear factor‐κB/MDR1 pathway in colorectal cancerSemantic proximity Read ↗

Krüppel-like factor 4 regulates stemness and mesenchymal properties of colorectal cancer stem cells through the TGF-β1/Smad/snail pathway.Semantic proximity Read ↗

CD133(+)CXCR4(+) colon cancer cells exhibit metastatic potential and predict poor prognosis of patients.Semantic proximity Read ↗

Overexpression of snail induces epithelial-mesenchymal transition and a cancer stem cell-like phenotype in human colorectal cancer cells.Semantic proximity Read ↗

Twist mediates an aggressive phenotype in human colorectal cancer cells.Semantic proximity Read ↗

Morusin inhibits the growth of human colorectal cancer HCT116‑derived sphere‑forming cells via the inactivation of Akt pathwaySemantic proximity Read ↗

Oct4 Gene Expression in Primary Colorectal Cancer Promotes Liver MetastasisSemantic proximity Read ↗

STIL-a novel link in Shh and Wnt signaling, endowing oncogenic and stem like attributes to colorectal cancerSemantic proximity Read ↗

Over-expression of Nanog predicts tumor progression and poor prognosis in colorectal cancerSemantic proximity Read ↗

Constitutive expression of Wnt/β-catenin target genes promotes proliferation and invasion of liver cancer stem cellsSemantic proximity Read ↗

Deficient or R273H and R248W Mutations of p53 Promote Chemoresistance to 5-FU via TCF21/CD44 Axis-Mediated Enhanced Stemness in Colorectal CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.