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Article

The association between CYP19 polymorphism and endometriosis risk: a system review and meta-analysis.

European journal of obstetrics, gynecology, and reproductive biology - 1 Apr 2016

Yi Ke, Yang LingYun, Lan Zhu, Xi MingRong

Abstract excerpt

OBJECTIVE: Endometriosis is a chronic, inflammatory, estrogen dependent disease. Genetic variation of estrogen biosynthesis and metabolic genes is associated with the risk of endometriosis. The CYP19 gene, encoding aromatase, plays an important role in the conversion of androgens to estrogens. Polymorphisms in the CYP19 gene are associated with circulating estrogen levels and estrogen/testosterone ratio. The aim...

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PMID: 26897397
DOI: 10.1016/j.ejogrb.2016.01.010

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