Article
Monoclonal antibodies against Hepatitis C genotype 3a virus like particle inhibit virus entry in cell culture system.
PloS one - 1 Jan 2013
Das Soma, Shetty Rohini K, Kumar Anuj, Shridharan Radhika Nagamangalam, Tatineni Ranjitha, Chi Giriprakash, Mukherjee Anirban, Das Saumitra, Subbarao Shaila Melkote, Karande Anjali Anoop
Abstract excerpt
The envelope protein (E1-E2) of Hepatitis C virus (HCV) is a major component of the viral structure. The glycosylated envelope protein is considered to be important for initiation of infection by binding to cellular receptor(s) and also known as one of the major antigenic targets to host immune response. The present study was aimed at identifying mouse monoclonal antibodies which inhibit binding of virus like...
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