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Article

Isolation of human monoclonal antibodies to the envelope e2 protein of hepatitis C virus and their characterization.

PloS one - 1 Jan 2013

Shimizu Yohko K, Hijikata Minako, Oshima Masamichi, Shimizu Kazufumi, Alter Harvey J, Purcell Robert H, Yoshikura Hiroshi, Hotta Hak

Abstract excerpt

We isolated and characterized two human monoclonal antibodies to the envelope E2 protein of hepatitis C virus (HCV). Lymphoblastoid cell lines stably producing antibodies were obtained by immortalizing peripheral blood mononuclear cells of a patient with chronic hepatitis C using Epstein-Barr virus. Screening for antibody-positive clones was carried out by immunofluorescence with Huh7 cells expressing the E2...

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Identifiers

PMID: 23409074
DOI: 10.1371/journal.pone.0055874
PMCID: PMC3567033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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