Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systematic fine-mapping of association with BMI and type 2 diabetes at the FTO locus by integrating results from multiple ethnic groups.

PloS one - 1 Jan 2014

Akiyama Koichi, Takeuchi Fumihiko, Isono Masato, Chakrawarthy Sureka, Nguyen Quang Ngoc, Wen Wanqing, Yamamoto Ken, Katsuya Tomohiro, Kasturiratne Anuradhani, Pham Son Thai, Zheng Wei, Matsushita Yumi, Kishimoto Miyako, Do Loi Doan, Shu Xiao-Ou, Wickremasinghe Ananda R, Kajio Hiroshi, Kato Norihiro

Abstract excerpt

BACKGROUND/OBJECTIVE: The 16q12.2 locus in the first intron of FTO has been robustly associated with body mass index (BMI) and type 2 diabetes in genome-wide association studies (GWAS). To improve the resolution of fine-scale mapping at FTO, we performed a systematic approach consisting of two pa...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Share to Asian People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Mass Index

Share to Diabetes Mellitus, Type 2

Share to FTO gene

Share to Linkage Disequilibrium

Share to Polymorphism, Single Nucleotide

Share to Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24978468
DOI: 10.1371/journal.pone.0101329
PMCID: PMC4076329

Genes

FTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24978468-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systematic fine-mapping of association with BMI and type 2 diabetes at the FTO locus by integrating results from multiple ethnic groups.PMID 24978468Read ↗

A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study.Semantic proximity Read ↗

Fine mapping of the association with obesity at the FTO locus in African-derived populations.Semantic proximity Read ↗

Integrative analysis of Mendelian randomization and Bayesian colocalization highlights four genes with putative BMI-mediated causal pathways to diabetes.Semantic proximity Read ↗

Fine mapping of type 2 diabetes susceptibility loci.Semantic proximity Read ↗

Fine Mapping and Identification of BMI Loci in African Americans.Semantic proximity Read ↗

Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals.Semantic proximity Read ↗

Mapping genes influencing type 2 diabetes risk and BMI in Japanese subjects.Semantic proximity Read ↗

Combining functional annotation and multi-trait fine-mapping methods improves fine-mapping resolution at glycaemic trait lociSemantic proximity Read ↗

Meta‐Analysis of Genome‐wide Linkage Studies in BMI and ObesitySemantic proximity Read ↗

FTO is a major genetic link between breast cancer, obesity, and diabetes.Semantic proximity Read ↗

A fine-mapping study of central obesity loci incorporating functional annotation and imputation.Semantic proximity Read ↗

A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.