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Article

Susceptibilities of herpes simplex viruses to penciclovir and acyclovir in eight cell lines.

Antimicrobial agents and chemotherapy - 1 Mar 2002

Leary Jeffry J, Wittrock Robert, Sarisky Robert T, Weinberg Adriana, Levin Myron J

Abstract excerpt

The commonly used antiviral drugs acyclovir (ACV) and penciclovir (PCV) possess similarly potent antiviral activities in vivo against herpes simplex virus (HSV). Assay methods for sensitivity to ACV are not necessarily transferable to PCV, even though the two drugs have similar in vivo potencies and mechanisms of action. We determined by plaque reduction assay the relative activities of ACV and PCV against five...

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Identifiers

PMID: 11850259
DOI: 10.1128/AAC.46.3.762-768.2002
PMCID: PMC127472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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