Article
Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2013
Chang Zhe, Li Zhongkui, Wang Xiaoyang, Kang Ya'an, Yuan Yuhui, Niu Jiangong, Wang Huamin, Chatterjee Deyali, Fleming Jason B, Li Min, Abbruzzese James L, Chiao Paul J
Abstract excerpt
PURPOSE: The most common genetic lesions in pancreatic ductal adenocarcinoma (PDAC) have been identified. However, significant gaps still exist in our understanding of how such genetic alterations act in concert to induce PDAC development. In this study, we investigated the mechanism of tumorigenic transformation in the immortalized human pancreatic ductal epithelial (HPDE) cell line by sequentially introducing...
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