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Article

Schizophrenia two-hit hypothesis in velo-cardio facial syndrome.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Mar 2013

Williams Hywel J, Monks Stephen, Murphy Kieran C, Kirov George, O'Donovan Michael C, Owen Michael J

Abstract excerpt

Deletion of chr22q11 gives rise to velo-cardio facial syndrome (VCFS) and increases schizophrenia risk. The source of this elevated risk although unknown could result from stochastic, environmental, or genetic factors, the latter encompassing a range of complexity from polygenic mechanisms to "se...

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PMID: 23335482
DOI: 10.1002/ajmg.b.32129

Genes

MBD5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23335482-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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