Polymorphic Ala-allele carriers at residue 1170 of HER2 associated with Parkinson's disease.

Abstract excerpt

OBJECTIVE: HER2, a receptor tyrosine kinase, was originally identified based on its role in cancer research. The protein has subsequently received attention for its role in nerve injury and neurodevelopment. We investigated the polymorphic association of HER2 variants at amino acid residues 655 and 1170 with Parkinson's disease (PD), a neurodegenerative disorder. DESIGN AND METHODS: Polymerase chain reaction...

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