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Article

Mechanism and implications of CXCR4-mediated integrin activation by Porphyromonas gingivalis.

Molecular oral microbiology - 1 Aug 2013

Hajishengallis G, McIntosh M L, Nishiyama S-I, Yoshimura F

Abstract excerpt

In monocytes and macrophages, the interaction of Porphyromonas gingivalis with Toll-like receptor 2 (TLR2) leads to the activation of a MyD88-dependent antimicrobial pathway and a phosphatidylinositol-3 kinase (PI3K) -dependent pro-adhesive pathway, which activates the β2 -integrin complement receptor 3 (CR3). By means of its fimbriae, P. gingivalis binds CXC-chemokine receptor 4 (CXCR4) and induces crosstalk...

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Source

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Identifiers

PMID: 23331495
DOI: 10.1111/omi.12021
PMCID: PMC4123224

Genes

CXCR4
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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