Article
CFTR inhibitors.
Current pharmaceutical design - 1 Jan 2013
Verkman Alan S, Synder David, Tradtrantip Lukmanee, Thiagarajah Jay R, Anderson Marc O
Abstract excerpt
The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a cAMP-regulated Cl- channel whose major function is to facilitate epithelial fluid secretion. Loss-of-function mutations in CFTR cause the genetic disease cystic fibrosis. CFTR is required for transepithelial fluid transport in certain secretory diarrheas, such as cholera, and for cyst expansion in autosomal dominant polycystic kidney...
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