Article
Emerging drug treatments for cystic fibrosis.
Expert opinion on emerging drugs - 1 Nov 2003
Zeitlin Pamela L
Abstract excerpt
Cystic fibrosis (CF) is one of the most common life-shortening inherited disorders. Mutations in the cystic fibrosis transmembrane regulator (CFTR) gene disrupt the localisation and function of the cAMP-mediated chloride channel. Most of the morbidity and mortality arise from the lung disease which is characterised by excessive inflammation and chronic infection. Research into the mechanisms of wild-type and...
Topics
- Anti-Infective Agents
- Anti-Inflammatory Agents
- Chloride Channels
- Chlorides
- Clinical Trials as Topic
- Codon, Terminator
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Drug Design
- Genetic Therapy
- Humans