A comparison of DNA adduct formation in white blood cells and internal organs of mice exposed to benzo[a]pyrene, dibenzo[c,g]carbazole, safrole and cigarette smoke condensate.

doi:10.1016/0165-1218(90)90107-d

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Article

A comparison of DNA adduct formation in white blood cells and internal organs of mice exposed to benzo[a]pyrene, dibenzo[c,g]carbazole, safrole and cigarette smoke condensate.

Mutation research - 1 May 1990

Reddy M V, Randerath K

Abstract excerpt

Measurement of tissue/cell DNA adducts represents a suitable monitor of carcinogen exposure because the majority of chemical mutagens/carcinogens react with DNA, forming covalent adducts, a key event in the initiation of chemical carcinogenesis. Investigations of DNA-adduct formation in vivo in w...

Topics

Animals
Benzo(a)pyrene
Carbazoles
DNA
Dioxoles
Female
Kidney
Leukocytes
Liver
Mice
Mice, Inbred ICR
Mutation
Plants, Toxic
Safrole
Smoke
Nicotiana

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