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Article

Effect of the expression of BRCA2 on spontaneous homologous recombination and DNA damage-induced nuclear foci in Saccharomyces cerevisiae.

Mutagenesis - 1 Mar 2013

Spugnesi Laura, Balia Cristina, Collavoli Anita, Falaschi Elisabetta, Quercioli Valentina, Caligo Maria Adelaide, Galli Alvaro

Abstract excerpt

The tumour-suppressor gene BRCA2 has been demonstrated to be involved in maintenance of genome integrity by affecting DNA double-strand break repair and homologous recombination. Protein-truncating mutations in BRCA2 predispose women to early onset breast and ovarian cancers and account for 15-30% of familial breast cancer risk. In contrast, the human cancer risk due to missense mutations, intronic variants, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23328489
DOI: 10.1093/mutage/ges069

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BRCA2

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