Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A recombination-based method to characterize human BRCA1 missense variants.

Breast cancer research and treatment - 1 Jan 2011

Guidugli Lucia, Rugani Chiara, Lombardi Grazia, Aretini Paolo, Galli Alvaro, Caligo Maria Adelaide

Abstract excerpt

Many missense variants in BRCA1 are of unclear clinical significance. Functional and genetic approaches have been proposed for elucidating the clinical significance of such variants. The purpose of this study was to evaluate BRCA1 missense variants for their effect on both homologous recombinatio...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to Breast Neoplasms
Share to BRCA1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to HeLa Cells

Share to Mutation, Missense

Share to Recombination, Genetic

Share to Transfection

Source

Identifiers

PMID: 20737206
DOI: 10.1007/s10549-010-1112-8

Genes

BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20737206-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A recombination-based method to characterize human BRCA1 missense variants.PMID 20737206Read ↗

A yeast recombination assay to characterize human BRCA1 missense variants of unknown pathological significance.Semantic proximity Read ↗

Functional analyses of rare germline BRCA1 variants by transcriptional activation and homologous recombination repair assays.Semantic proximity Read ↗

Functional Categorization of BRCA1 Variants of Uncertain Clinical Significance in Homologous Recombination Repair Complementation Assays.Semantic proximity Read ↗

[Evaluation of variants of unknown significance in the BRCA2 gene].Semantic proximity Read ↗

Effect of the expression of BRCA2 on spontaneous homologous recombination and DNA damage-induced nuclear foci in Saccharomyces cerevisiae.Semantic proximity Read ↗

Validation and Data-Integration of Yeast-Based Assays for Functional Classification of BRCA1 Missense Variants.Semantic proximity Read ↗

A high-throughput functional complementation assay for classification of BRCA1 missense variants.Semantic proximity Read ↗

Breast cancer risk and the DNA double-strand break end-joining capacity of nonhomologous end-joining genes are affected by BRCA1.Semantic proximity Read ↗

A naturally occurring mutation in an ATP-binding domain of the recombination repair gene XRCC3 ablates its function without causing cancer susceptibility.Semantic proximity Read ↗

The c.5242C>A BRCA1 missense variant induces exon skipping by increasing splicing repressors binding.Semantic proximity Read ↗

A naturally occurring genetic variant of human XRCC2 (R188H) confers increased resistance to cisplatin-induced DNA damage.Semantic proximity Read ↗

Mechanism for survival of homozygous nonsense mutations in the tumor suppressor gene BRCA1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.