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Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis

16 Jan 2013

Abstract excerpt

Our studies in HUVECs show that ox-LDL induced autophagy and damaged mtDNA leading to TLR9 expression. LOX-1 antibody or the ROS inhibitor apocynin attenuated ox-LDL-mediated autophagy, mtDNA damage and TLR9 expression, suggesting that these events are LOX-1 and ROS-dependent phenomena. Experiments using siRNA to DNase II indicated that DNase II digests mtDNA to protect the tissue from inflammation. Next, we...

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PMID: 23326634
DOI: 10.1038/srep01077

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