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Article

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure.

Nature - 10 May 2012

Oka Takafumi, Hikoso Shungo, Yamaguchi Osamu, Taneike Manabu, Takeda Toshihiro, Tamai Takahito, Oyabu Jota, Murakawa Tomokazu, Nakayama Hiroyuki, Nishida Kazuhiko, Akira Shizuo, Yamamoto Akitsugu, Komuro Issei, Otsu Kinya

Abstract excerpt

Heart failure is a leading cause of morbidity and mortality in industrialized countries. Although infection with microorganisms is not involved in the development of heart failure in most cases, inflammation has been implicated in the pathogenesis of heart failure. However, the mechanisms responsible for initiating and integrating inflammatory responses within the heart remain poorly defined. Mitochondria are...

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Source

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Identifiers

PMID: 22535248
DOI: 10.1038/nature10992
PMCID: PMC3378041

Genes

TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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