Article
Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress.
Free radical research - 1 Oct 2005
Li Hong Mei, Niki Takeshi, Taira Takahiro, Iguchi-Ariga Sanae M M, Ariga Hiroyoshi
Abstract excerpt
DJ-1 is a novel oncogene and causative gene for familial form of the Parkinson's disease (PD). DJ-1 has been shown to play a role in anti-oxidative stress by eliminating reactive oxygen species (ROS). The onset of PD is thought to be caused by oxidative stress and mitochondrial injury, which leads to protein aggregation that results in neuronal cell death. However, the mechanism by which DJ-1 triggers the onset...
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