Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis.

Human molecular genetics - 15 Jul 2005

Zhang Li, Shimoji Mika, Thomas Bobby, Moore Darren J, Yu Seong-Woon, Marupudi Neena I, Torp Reidun, Torgner Ingeborg A, Ottersen Ole P, Dawson Ted M, Dawson Valina L

Abstract excerpt

Both homozygous (L166P, M26I, deletion) and heterozygous mutations (D149A, A104T) in the DJ-1 gene have been identified in Parkinson's disease (PD) patients. The biochemical function and subcellular localization of DJ-1 protein have not been clarified. To date the localization of DJ-1 protein has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Electrophoresis, Polyacrylamide Gel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Microscopy, Electron

Share to Oncogene Proteins

Share to Parkinson Disease

Share to Protein Deglycase DJ-1

Share to Subcellular Fractions

Source

Identifiers

PMID: 15944198
DOI: 10.1093/hmg/ddi211

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15944198-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis.PMID 15944198Read ↗

Unexpected mitochondrial matrix localization of Parkinson's disease-related DJ-1 mutants but not wild-type DJ-1.Semantic proximity Read ↗

Monomer DJ-1 and its N-terminal sequence are necessary for mitochondrial localization of DJ-1 mutants.Semantic proximity Read ↗

Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction.Semantic proximity Read ↗

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress.Semantic proximity Read ↗

L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system.Semantic proximity Read ↗

DJ‐1 is present in a large molecular complex in human brain tissue and interacts with α‐synucleinSemantic proximity Read ↗

L10p and P158DEL DJ-1 mutations cause protein instability, aggregation, and dimerization impairments.Semantic proximity Read ↗

Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function.Semantic proximity Read ↗

Mitochondrial localization of DJ-1 leads to enhanced neuroprotection.Semantic proximity Read ↗

BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activitySemantic proximity Read ↗

Parkinson’s associated protein DJ-1 regulates intercellular communication via extracellular vesicles in oxidative stress.Semantic proximity Read ↗

L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.