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Article

Practical considerations regarding the use of genotype and pedigree data to model relatedness in the context of genome-wide association studies.

G3 (Bethesda, Md.) - 3 Oct 2013

Cheng Riyan, Parker Clarissa C, Abney Mark, Palmer Abraham A

Abstract excerpt

Genome-wide association studies of complex traits often are complicated by relatedness among individuals. Ignoring or inappropriately accounting for relatedness often results in inflated type I error rates. Either genotype or pedigree data can be used to estimate relatedness for use in mixed-models when undertaking quantitative trait locus mapping. We performed simulations to investigate methods for controlling...

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Identifiers

PMID: 23979941
DOI: 10.1534/g3.113.007948
PMCID: PMC3789811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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