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Article

Novel mechanisms of TolC-independent decreased bile-salt susceptibility in Escherichia coli.

FEMS microbiology letters - 1 May 2020

Le Vuong Van Hung, Biggs Patrick J, Wheeler David, Davies Ieuan G, Rakonjac Jasna

Abstract excerpt

Bile salts, including sodium deoxycholate (DOC), are secreted into the intestine to aid fat digestion and contribute to antimicrobial protection. Gram-negative pathogens such as Escherichia coli, however, are highly resistant to DOC, using multiple mechanisms of which the multidrug efflux pump AcrAB-TolC is the dominant one. Given that TolC-mediated efflux masks the interaction of DOC with potential targets, we...

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PMID: 32407499
DOI: 10.1093/femsle/fnaa083

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