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Article

Characterization of a Mycobacterium smegmatis mutant that is simultaneously resistant to D-cycloserine and vancomycin.

Antimicrobial agents and chemotherapy - 1 Jun 2000

Peteroy M, Severin A, Zhao F, Rosner D, Lopatin U, Scherman H, Belanger A, Harvey B, Hatfull G F, Brennan P J, Connell N D

Abstract excerpt

A mutant of Mycobacterium smegmatis has been isolated that is simultaneously resistant to both D-cycloserine (D-CS) and vancomycin. Genetic complementation with a PBP4 homolog restores sensitivity to both drugs. Resistance to D-CS and vancomycin in this mutant is most likely due to a novel mechanism involving peptidoglycan assembly at the cell surface.

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Source

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Identifiers

PMID: 10817733
DOI: 10.1128/AAC.44.6.1701-1704.2000
PMCID: PMC89937

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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