Article

CD28-Selective Inhibition Prolongs Non-Human Primate Kidney Transplant Survival

2023-05-05

Abstract excerpt

Costimulation blockade using belatacept results in improved renal function after kidney transplant as well as decreased likelihood of death/graft loss and reduced cardiovascular risk; however, higher rates and grades of acute rejection have prevented its widespread clinical adoption. Treatment with belatacept blocks both positive (CD28) and negative (CTLA-4) T cell signaling. CD28-selective therapies may offer imp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 22a74a25-3fac-58a9-8e19-724ca88eba43
DOI: 10.1101/2023.05.03.539333

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CD28-Selective Inhibition Prolongs Non-Human Primate Kidney Transplant SurvivalDOI 10.1101/2023.05.03.539333Read

Belatacept and sirolimus prolong nonhuman primate renal allograft survival without a requirement for memory T cell depletion.Semantic proximity Read

Translating costimulation blockade to the clinic: lessons learned from three pathwaysSemantic proximity Read

Developments in kidney xenotransplantationSemantic proximity Read

Preclinical Testing of Antihuman CD28 Fab' Antibody in a Novel Nonhuman Primate Small Animal Rodent Model of Xenogenic Graft-Versus-Host Disease.Semantic proximity Read

Alefacept promotes immunosuppression-free renal allograft survival in nonhuman primates via depletion of recipient memory T cells.Semantic proximity Read

ABO-compatible liver allograft antibody-mediated rejection: an update.Semantic proximity Read

Clinical and Histological Phenotypes of Antibody-Mediated Rejection in Kidney Transplant: A Single-Center Experience from Latin America.Semantic proximity Read

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunitySemantic proximity Read

New molecules in the therapy of chronic graft-versus-host diseaseSemantic proximity Read

Immune suppression in cynomolgus monkeys by XPro9523: an improved CTLA4-Ig fusion with enhanced binding to CD80, CD86 and neonatal Fc receptor FcRn.Semantic proximity Read

Effects of an agonist interleukin-2/Fc fusion protein, a mutant antagonist interleukin-15/Fc fusion protein, and sirolimus on cardiac allograft survival in non-human primates.Semantic proximity Read

Anti-CD28 antibody-induced kidney allograft tolerance related to tryptophan degradation and TCR class II B7 regulatory cells.Semantic proximity Read