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Host Alloreactive Memory T Cells Influence Tolerance to Kidney Allografts in Nonhuman Primates

8 Jun 2011

Abstract excerpt

Transplant tolerance, defined as indefinite allograft survival without immunosuppression, has been regularly achieved in laboratory mice but not in nonhuman primates or humans. In contrast to laboratory mice, primates regularly have high frequencies of alloreactive memory T cells (TMEMs) before transplantation. These TMEMs are poorly sensitive to conventional immunosuppression and costimulation blockade, and the...

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PMID: 21653831
DOI: 10.1126/scitranslmed.3002093

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