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Article

Systems biology approach reveals genome to phenome correlation in type 2 diabetes.

PloS one - 1 Jan 2013

Jain Priyanka, Vig Saurabh, Datta Malabika, Jindel Dinesh, Mathur Ashok Kumar, Mathur Sandeep Kumar, Sharma Abhay

Abstract excerpt

Genome-wide association studies (GWASs) have discovered association of several loci with Type 2 diabetes (T2D), a common complex disease characterized by impaired insulin secretion by pancreatic β cells and insulin signaling in target tissues. However, effect of genetic risk variants on continuous glycemic measures in nondiabetic subjects mainly elucidates perturbation of insulin secretion. Also, the disease...

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Identifiers

PMID: 23308243
DOI: 10.1371/journal.pone.0053522
PMCID: PMC3538588

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Source receipt: pubmed, retrieved 7 Sept 2026.

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