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Article

Interactome-transcriptome analysis discovers signatures complementary to GWAS Loci of Type 2 Diabetes.

Scientific reports - 18 Oct 2016

Li Jing-Woei, Lee Heung-Man, Wang Ying, Tong Amy Hin-Yan, Yip Kevin Y, Tsui Stephen Kwok-Wing, Lok Si, Ozaki Risa, Luk Andrea O, Kong Alice P S, So Wing-Yee, Ma Ronald C W, Chan Juliana C N, Chan Ting-Fung

Abstract excerpt

Protein interactions play significant roles in complex diseases. We analyzed peripheral blood mononuclear cells (PBMC) transcriptome using a multi-method strategy. We constructed a tissue-specific interactome (T2Di) and identified 420 molecular signatures associated with T2D-related comorbidity and symptoms, mainly implicated in inflammation, adipogenesis, protein phosphorylation and hormonal secretion. Apart...

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Share to Diabetes Mellitus, Type 2
Share to Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Leukocytes, Mononuclear

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

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Source

Open in PubMed Open full text

Identifiers

PMID: 27752041
DOI: 10.1038/srep35228
PMCID: PMC5067504

Genes

SRRT
JAZF1
MAOB
MLST8
NCOR2
PPARD
SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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